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Image Search Results
Journal: Nature communications
Article Title: Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring.
doi: 10.1038/s41467-025-55941-8
Figure Lengend Snippet: Fig. 3 | Pulmonary immune changes in embryonic life affect adult allergic responses. a Flow cytometric analysis of fetal lungs from asthmatic or control mothers (day 18 of fetal life); ILC2s were stimulated with PMA/ionomycin for 4 h, and cytokine production was assessed by intracellular staining. b Model of maternal anti-IL-7Rα treatment in late pregnancy. Female mice developed asthma during pregnancy (Fig. 1a) and were treated intravenously with isotype or anti-IL- 7Rα antibodies on days 14, 16, and 18 of gestation. c Adult offspring of antibody- treated asthmatic mothers received PBS or HDM intranasally (Fig. 1a). Changes in eosinophil and ILC2 cell numbers in the lungs of adult offspring; ILC2s were
Article Snippet: For depletion of fetal ILC2, IL-7Ra blockade was performed by intravenous injection of 200 μg isotype control (BioXCell, BE0089) or
Techniques: Control, Staining